Sickle Cell Disease (SCD) – Overview

Sickle Cell Disease (SCD) is an inherited blood disorder caused by a mutation in the hemoglobin gene, leading to the production of abnormal hemoglobin S.

Health Apr 21, 2025 26 Add to Reading List

This results in the formation of rigid, sickle-shaped red blood cells that block blood flow and reduce oxygen supply to tissues. The disease is linked to chronic pain, anemia, a heightened risk of infections, organ damage, and other severe complications. SCD predominantly affects individuals of African, Mediterranean, Middle Eastern, and Indian descent. Treatment strategies are aimed at managing symptoms, preventing complications, and improving the quality of life through advanced therapies and comprehensive care.

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Epidemiological Segmentation of SCD (2020–2034) – 6MM

Total Prevalence
Diagnosed Prevalence
Prevalence by SCD Type
Number of Treated Cases

SCD Epidemiology (2023 Insights)
In 2023, Sickle Cell Disease affected approximately 161,000 individuals across the six major markets (6MM).
The United States accounted for around 65% of these cases, reflecting the substantial burden of the disease.
Within the U.S., the 18–44 age group had the highest prevalence, emphasizing the impact of SCD on young, working-age individuals.

SCD Market Overview
The Sickle Cell Disease market across the 6MM was valued at around USD 650 million in 2023.

Market Drivers

Advances in gene-editing technologies and disease-modifying therapies are transforming the SCD treatment landscape, offering potential long-term benefits.
Increased awareness, earlier diagnosis, and enhanced support from governments and advocacy groups are driving market growth and improving patient access.

Market Challenges

High treatment costs and inadequate healthcare infrastructure in low-income regions hinder access to advanced therapies.
Regulatory and clinical trial complexities can delay the development and approval of new treatments.

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Promising Emerging Therapies